PSP, Coriolus polysaccharide, intra-cellular mycelia extract of Coriolus Versicolor

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When studied with modern clinical science, many species of mushrooms commonly used in traditional Asian medicine have been found to possess powerful biological activities. Coriolus Versicolor (formerly Trametes

Known as the "Turkey Tail" in North America, Coriolus can be found in the wooded temperate zones of the Northern Hemisphere. In China, it is known as "Cloud Mushroom", and in Japan, it is called "Kawaratake".

Versicolor)has been one of the most

thoroughly researched and probably still has the most long term human studies in this group.

PSP-scientifically proven extract from Coriolus
A number of chemically distinct extracts are produced from Coriolus, including PSP, a Polysaccharde-Peptide, and PSK, a protein-bound polysaccharide.

These immune stimulating compounds are well known, considered to act as "biological response modifiers," making them the world's best-selling drugs for cancer therapy.

In 1980's, Chinese researchers isolated PSP from the mycelia of Coriolus Cov-1 strain. It is chemically similar to PSK, but differs from PSK in its strain, monosaccharide composition and molecular weight.

With over 480 double-blind clinical studies, PSP has been proven to have potent immune stimulating and anti-tumor capacities, at a total effective rate over 80%.



Terms	PSP	PSK
Strain	Cov-1	CM-101
Material	Liquid cultured mycelia	Fermented mycelia

Extraction Method	Hot water extract, precipitate with ethanol	Hot water extract, precipitate with (NH4)2SO4

Mono- saccharide	Galactose Mannose Xylose Arabinose+ Rhamnose+ Glucose+ Fucose-	Galactose Mannose Xylose Arabinose- Rhamnose- Glucose- Fucose+

Glucans	a(1-4), b(1-3), and b(1-6)	b(1-4), b(1-3), and b(1-6)

Molecular w.	100,000 Da	94,000 Da



Terms	PSP	Fruitbodies Extract
UV Spectrum	Max. abs. at 420, 487 nm	Max. abs. at 486, 671 nm

IR Spectrum	Obvious abs. at 1,380 nm	No obvious abs. at 1,380 nm

Polysaccharides	20%~35%	40%~50%

Mono- saccharide	Galactose+ Mannose Xylose Arabinose Rhamnose Glucose Fucose	Galactose- Mannose Xylose Arabinose Rhamnose Glucose Fucose

Clinically Proven Usage	Anti-cancers and Immune stimulation++	Treat Hepatitis B and Immune enhancement+

Although the polysaccharide portion of a fruitbody derived extract is similar to PSP, it has no peptides and is still not a PSP. Where there is polysaccharide there is polypeptide.1

Historically studies of PSP have used only mycelia derived extracts but never fruitbodies. The variations in its mycelia cultivations make PSP to be unique and chemically different than a fruitbody derived extract in its monosaccharide composition (PSP has Galactose, see

table 2.) and in its protein part (PSP has peptides).

MYCOPHARMA® Coriolus PSP Gold is an intra-cellular extract from mycelia of Coriolus Versicolor. The mycelium is produced through the deep layer cultivation. This is the only known process capable of producing highest quality of mycelium, to yield purest and most potent mycelium as for the raw material.

MYCOPHARMA® Coriolus PSP Gold is tested with Nuclear Magnetic Resonance imaging to confirm that it has the same chemical structure as the PSP used in the original research

1.RICHARD SULLIVAN BSc MD PhD 2006. EXTRACTION, DEVELOPMENT AND CHEMISTRY OF ANTI-CANCER COMPOUNDS FROM MEDICINAL MUSHROOMS 5. 22